Prior to using Depakote, notify your Health care provider about your entire professional medical circumstances which includes when you: have or have experienced liver issues.
Valproate should not be utilised to deal with Gals with epilepsy or bipolar ailment who are pregnant or who plan to become Expecting unless other medications have unsuccessful to deliver adequate symptom Command or are if not unacceptable.
Disclaimer: Our target is always to provide you with by far the most relevant and latest details. Nonetheless, due to the fact medicines affect Everybody differently, we are unable to promise that this information and facts contains all probable Uncomfortable side effects.
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Tend not to travel a car or truck, operate hazardous machinery, or do unsafe functions right until you know how Depakote affects you. Depakote can slow your considering and motor expertise and will influence your eyesight.
Divalproex sodium is utilised to take care of certain varieties of seizures (epilepsy). This medication is really an anticonvulsant that actually works in the brain tissue to stop seizures.
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Concurrent use of valproate and amitriptyline has almost never been linked to toxicity. Checking of amitriptyline amounts must be regarded for people getting valproate concomitantly with amitriptyline. Thought need to be specified to decreasing the dose of amitriptyline/nortriptyline during the existence of valproate.
Simply call your health practitioner without delay When you've got major Unintended effects. Connect with 911 or your neighborhood unexpected emergency providers or visit the nearest crisis place When your indicators truly feel lifestyle-threatening or if you think you’re aquiring a clinical unexpected emergency. Major Uncomfortable side effects and their signs and symptoms can include the next:
Carcinogenesis Valproate more info was administered orally to rats and mice at doses of eighty and a hundred and seventy mg/kg/working day (less than the maximum proposed human dose on the mg/m2 foundation) for 2 years.
are breastfeeding. Depakote can pass into breast milk and will damage your newborn. Talk to your healthcare supplier about The easiest way to feed your newborn if you take Depakote.
Verify with the health care Expert if any of the following side effects go on or are bothersome or Should you have any questions on them:
No recommendation regarding the protection of valproate for use at doses earlier mentioned 60 mg/kg/day is usually created. The chance of thrombocytopenia increases drastically at total trough valproate plasma concentrations previously mentioned 110 mcg/mL in women and a hundred thirty five mcg/mL in males. The advantage of enhanced seizure Manage with bigger doses needs to be weighed versus the potential of a larger incidence of adverse reactions.